Kisspeptin-10 is a short bioactive fragment of the kisspeptin family that acts via the GPR54 (KISS1R) receptor and is widely studied in basic neuroendocrine research for its role as a potent stimulator of GnRH neurons. Preclinical investigations across mammalian models demonstrate kisspeptin peptides potently activate the hypothalamic–pituitary–gonadal neurocircuitry, and mechanistic studies describe how kisspeptin signaling integrates metabolic and environmental cues with reproductive hormone control; contemporary reviews collate molecular, neuroanatomical, and gene-expression data that position kisspeptin as a master regulator of reproductive axis activation in nonclinical settings.

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