Selank is a synthetic heptapeptide derived from the immunomodulatory domain of human tuftsin that has been widely studied in cellular and animal models for anxiolytic, neuroprotective, and gene-regulatory effects. Preclinical studies report Selank-dependent modulation of monoaminergic and GABAergic systems, regulation of stress-responsive gene expression, and synergistic interactions with conventional anxiolytics in rodent assays; molecular investigations emphasize its effects on cytokine profiles, neurotrophin signaling, and transcriptomic shifts consistent with improved resilience to stressors in nonclinical systems.

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